Drug+Design

=__**Drug Design**__=

__**What are Drugs?**__
Most drugs are a designed composition of different elements that interact with a pre-determined biological target. This small molecules then bind, moderate and modulate the activities of such target.

__**But what are Biological Targets?**__
Well, This biological target are proteins that bind or interact with other molecules in order to achieve several different functions to ensure our well-being.

=__**Then What is Drug Design?**__=

Patience we are getting there.. When this biological Target fail, due to physiologic stressors or Genetic abnormalities, their functions are not completed and hence our well-being is threatened. You might notice the receptors failing in every-day life... in mild symptoms such as Runny noses or more advanced ones such as Depression. The roll of drugs is to correct this aberrations by performing the functions the failed biological target couldn't perform.

An example of a successful drug, known for performing

=__**But... What is Drug Design?**__=

In the case that certain types of receptors are failing a Drug is administered to inhibit the role of a protein and thus correct the effects of the failed biological target. Drug design is basically creating drugs with target receptors, enzymes or proteins, fulfilling their duty and preventing their harm to the persons well-being.

Well, another thing we must remember that the drug created must also be ideal in shape and charge to the biomolecular target (Enzyme, Protein, Receptor), so that the drug binds tightly with it, this is why drug design is also known as ligand design. Ligand design is solely the creation of a small molecule that binds tightly with its biological target. However, ligand design also does not limit it-self to the optimal binding of the drug molecules with their target, but also consider the: reduction of side-effect, bioavailability or metabolic half-life. These Ligands must first be thouroughly optimized before the drug can become compatible, safe and ready.

__ **T** ____ **hat makes sense... but how do you make a Drug?** __
==

First of all there are two types of drug design:

Ligand Based and Structure Based

__**Ligand Based:**__ (Indirect Drug Design) When the knowledge of the surrounding molecules of the target is used to re-create a model of the target that in turn is used to create drugs for.

__**Structure Based:**__ (Direct Drug Design) This is creating a 3-D model of the target by use of the knowledge obtained about the target. [|Drug design example]